Oocyte cryopreservation: a narrative review Abstract
Carina CW CHAN
Hong Kong Reproductive Health Centre
William WK SO
Premier Medical Centre
Oocyte cryopreservation is a method to preserve fertility for young cancer patients. Its indications have been extended
to include the quarantine and storage of donor oocytes in egg donation programs, women with medical conditions
that may culminate in premature ovarian insufficiency, and women who wish to safeguard fertility decline associated
with ageing. In this review, we discuss the history of oocyte cryopreservation and its various clinical applications,
with a focus on the safety of the procedure for cancer patients, especially those with hormone-dependent cancers
such as breast cancers. We also discuss ethical considerations for women who are cryopreserving their oocytes to
protect against age-related fertility loss, the optimal age to undergo oocyte cryopreservation, and the optimal number
of oocytes to freeze. The risks associated with the procedure and potential risks to children born from cryopreserved
oocytes are also addressed.
Hong Kong Reproductive Health Centre
William WK SO
Premier Medical Centre
Hong Kong J Gynaecol Obstet Midwifery 2021; 21(1):53–60